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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MARK1
All Species:
30.3
Human Site:
S435
Identified Species:
55.56
UniProt:
Q9P0L2
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P0L2
NP_061120.3
795
89003
S435
P
S
I
P
P
A
V
S
Y
T
K
R
P
Q
A
Chimpanzee
Pan troglodytes
XP_001172839
796
89049
S435
P
S
I
P
P
A
V
S
Y
T
K
R
P
Q
A
Rhesus Macaque
Macaca mulatta
XP_001115611
778
86745
S421
P
A
I
P
T
S
N
S
Y
S
K
K
T
Q
S
Dog
Lupus familis
XP_536123
782
87409
S422
P
S
I
P
P
A
V
S
Y
T
K
R
P
Q
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8VHJ5
795
88528
S435
P
S
I
P
P
A
V
S
Y
T
K
R
P
Q
A
Rat
Rattus norvegicus
O08678
793
88216
S435
P
S
I
P
P
A
V
S
Y
T
K
R
P
Q
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511751
793
88836
S434
P
A
I
P
P
A
V
S
Y
T
K
R
S
Q
A
Chicken
Gallus gallus
Q9IA88
798
88848
C407
S
L
Q
A
E
M
D
C
D
M
N
N
P
L
Q
Frog
Xenopus laevis
NP_001085126
792
88624
S435
P
S
I
P
P
S
V
S
Y
T
K
R
G
Q
A
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
A489
P
F
P
P
L
M
P
A
L
A
Q
M
Q
L
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
G548
R
S
S
A
T
A
T
G
A
S
I
T
A
G
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
L164
I
K
I
A
D
F
G
L
S
N
V
M
R
D
G
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
R285
G
A
A
G
L
I
K
R
M
L
I
V
N
P
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
68.9
95.9
N.A.
94.9
94.3
N.A.
92.8
30.4
88.6
27.8
N.A.
N.A.
N.A.
40.7
N.A.
Protein Similarity:
100
99.3
80.2
96.8
N.A.
97.3
96.9
N.A.
95.9
51.3
94.2
44
N.A.
N.A.
N.A.
51
N.A.
P-Site Identity:
100
100
46.6
100
N.A.
100
100
N.A.
86.6
6.6
86.6
13.3
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
100
80
100
N.A.
100
100
N.A.
93.3
6.6
93.3
26.6
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.9
28
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.4
46.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
24
8
24
0
54
0
8
8
8
0
0
8
0
54
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
8
0
8
0
0
0
0
8
0
% D
% Glu:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
8
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
8
0
0
8
8
0
0
0
0
8
8
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
70
0
0
8
0
0
0
0
16
0
0
0
0
% I
% Lys:
0
8
0
0
0
0
8
0
0
0
62
8
0
0
0
% K
% Leu:
0
8
0
0
16
0
0
8
8
8
0
0
0
16
8
% L
% Met:
0
0
0
0
0
16
0
0
8
8
0
16
0
0
8
% M
% Asn:
0
0
0
0
0
0
8
0
0
8
8
8
8
0
0
% N
% Pro:
70
0
8
70
54
0
8
0
0
0
0
0
47
8
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
8
0
8
62
8
% Q
% Arg:
8
0
0
0
0
0
0
8
0
0
0
54
8
0
0
% R
% Ser:
8
54
8
0
0
16
0
62
8
16
0
0
8
0
16
% S
% Thr:
0
0
0
0
16
0
8
0
0
54
0
8
8
0
0
% T
% Val:
0
0
0
0
0
0
54
0
0
0
8
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
62
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _